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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are typically described as a focus on the practical aspects of designing a study which include the recruitment and consent process, as well as adherence and the use routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed different investigators and participants from different geographical regions. This type of heterogeneity is necessary for pragmatic trials to be able to prove their validity and reduces bias in the results. However excessive heterogeneity could result in issues with the design of the trial.

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The purpose of pragmatic trials is to mimic real-life situations and achieve the highest level of validity externally. They are usually requested by policy makers and practitioners to aid in their decision-making. They are also a good method to determine the cause-effect relationship between an intervention and its outcomes. They should, however, not be used to replace explanation studies.

The idea of pragmatism is controversial and 프라그마틱 홈페이지 there are doubts regarding whether pragmatic trials could be used to replace explanation tests or if they should be a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which prove the validity of a clinical or physiological hypothesis as well as pragmatic trials, which inform the policy and practice of. They also suggested the framework for pragmatic trials, which they called PRECIS.2 This tool attempted to define the characteristics of a practical trial, including recruitment, design and delivery of the intervention, and follow-up.

There is an encouraging increase in the number of pragmatic trials published. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs), yielded 34 articles, shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatism. It is important to note, however, that the majority were conducted in primary care settings.