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Pragmatic trials are those that are designed to inform real-world clinical practice. They are typically described by their focus on practical aspects of study design, including the recruitment and consent process, as well as adherence and the use routinely available equipment.
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A pragmatic study that involves a variety investigators and includes participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is required for practical trials to be valid, and it also helps reduce bias in the results. However excessive heterogeneity could cause issues with the design of the trial.
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Pragmatic trials aim to mimic real-life situations and attain maximum external validity. They are usually requested by practitioners and 프라그마틱 공식홈페이지 정품확인방법 (https://www.google.ki/url?q=https://puckett-lau.blogbright.net/are-you-sick-of-pragmatic-Product-authentication-10-inspirational-ideas-to-invigorate-your-love) policy makers to inform their decision making. They can also be a great way to identify the causal relationship between an intervention and its results. However, they should not, be used to replace the need for explanation studies.
The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate the validity of a clinical or physiological hypothesis as well as pragmatic trials that inform the practice and policy decisions. They also suggested an approach to pragmatic trials, which they called PRECIS.2 This tool attempted to define the elements of a practical trial, including the recruitment process, the design and delivery of the intervention, as well as monitoring.
There is a growing trend in the number of pragmatic trials that are published. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This is an indication that the health science community is becoming more sensitive to the subject of pragmatics. It is important to note, however, that the majority of these studies were conducted in primary-care settings.