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Pragmatic trials are those that are designed to provide information for real-world clinical practice. They are typically characterized by a focus on the practical aspects of the study design, such as the recruitment process and consent in adherence, as well as the use of standard equipment.

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Pragmatic, a software company, offers a variety of casino games to online gambling platforms. Pragmatic's iGaming software is used by leading operators as well as land-based casinos. The company offers front-end site design tools, analysis and marketing, promotions, security payment systems, customer support and bug-reporting. Additionally, the company offers its players a secure environment with high-quality graphics and gaming.

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A pragmatic study that involves various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, that is crucial for pragmatic trials to be reliable and reduce bias in results, is also necessary. However, too much heterogeneity can cause problems with the design of the trial.

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Pragmatic Play is renowned for its top-notch games, and for offering an exceptional user experience. Its software is designed to work on mobile devices and supports various languages. It has established itself as one of the top casino gaming platforms despite its relative youth. Its latest releases include Wolves which is a five-reel video slot with a healthful RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

The aim of pragmatic trials is to simulate real-life situations and achieve maximum validity externally. They are typically ordered by policymakers and practitioners to inform their decisions. They can be used to determine the causality of an intervention and its results. However, they should not be used as a substitute for explanatory trials.

The pragmatism idea is controversial, and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm a physiological or clinical hypothesis as well as pragmatic trials, which inform the practice and policy decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the traits of a pragmatic study which includes recruitment, design, delivery of the intervention and its follow-up.

The number of pragmatic trials is growing. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This is an indication that the health sciences community is becoming more sensitive to the subject of pragmatism. It is important to remember that the majority of studies were conducted in primary-care settings.