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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often focused on the practical aspects of the study design, including the recruitment process and consent as well as adherence to the use of commonly available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and had participants from different geographic areas. This kind of heterogeneity, which is vital for pragmatic trials to be reliable and to reduce bias in the results, is also necessary. However too much heterogeneity could cause problems with the design of the trial.

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Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. Usually, they are requested by practitioners and policymakers to help guide their decisions. They can also be used to assess the cause-effect relationship of an intervention and its results. However, they shouldn't be used in lieu for explanation studies.

The idea of pragmatism is controversial, and there are questions about whether pragmatic trials can be used to replace explanation tests or if they are an addition to them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which prove the validity of a physiological or clinical hypothesis, as well as pragmatic trials, that inform the decision-making process for policy and practice. They also proposed a framework called PRECIS for 프라그마틱 추천 무료슬롯 프라그마틱 (Https://Listbell.Com/Story7774332/14-Smart-Strategies-To-Spend-The-Remaining-Live-Casino-Budget) pragmatic trials.2 This tool tried to define the elements of a pragmatic study that includes recruitment, design, implementation of the intervention and follow-up.

The number of pragmatic trials is growing. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs) resulted in 34 articles, shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.