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Pragmatic trials are studies designed to provide information for the practice of clinical trials in real life. They are often characterized as focusing on practical aspects of study design which include the recruitment and consent process, as well as adherence and the use of routinely available equipment.

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A pragmatic trial that uses different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is vital for pragmatic trials to be valid and reduce bias in results, 프라그마틱 무료게임 is also necessary. Too much heterogeneity, however, can cause problems with the trial design.

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The aim of pragmatic trials is to simulate real-life situations and achieve the highest level of validity externally. They are typically commissioned by policymakers and practitioners to guide their decisions. They can also be a great way to identify the cause-effect relationship between an intervention and its results. However, they shouldn't be used as a substitute for the use of explanation studies.

The idea of pragmatism is controversial and there are concerns about whether pragmatic trials can replace explanatory tests or if they should serve as an alternative to them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which support the validity of a physiological or clinical hypothesis, as well as pragmatic trials, which inform the practice and policy decision-making. They also proposed a framework for pragmatic trials, dubbed PRECIS.2 This tool sought to define the features of a practical trial that include the recruitment process, the design and delivery of the intervention, as well as monitoring.

The number of pragmatic trials is increasing. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs), yielded 34 articles, shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to note that the majority of these studies were conducted in primary care settings.