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Studies designed to provide insight into clinical practice in the real world are known as pragmatic trials. They are often described as a focus on the practical aspects of design, including the recruitment and consent process, as well as adherence and the use of routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and participants from different geographic areas. This type of heterogeneity, that is crucial for a pragmatic trial to be reliable and lessen the chance of bias, is also necessary. A high degree of heterogeneity, however can result in problems with the design of the trial.

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The aim of pragmatic trials is to mimic real-life scenarios and gain the highest level of validity externally. They are typically commissioned by policy makers and practitioners to aid in their decision-making. They can also be used to determine the causality of an intervention and its results. However, they should not, be used to replace explanation studies.

The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm the validity of a clinical or physiological hypothesis and pragmatic trials, which inform policy and practice decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic study that includes the recruitment, design, 프라그마틱 정품확인 무료체험 메타 (alphabookmarking.com) and delivery of the intervention and its follow-up.

There is a growing increase in the number of pragmatic trials published. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), 프라그마틱 슈가러쉬 환수율 (click through the next site) returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming more sensitive to the issue of pragmatics. It is important to note, however, that the majority of these studies were conducted in primary care settings.